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Indications
Salbutamol Inhaler is indicated for the treatment of reversible airway obstruction brought on by bronchitis and emphysema as well as for the treatment of bronchospasm in bronchial asthma.
Exercise-Induced Bronchospasm: Salbutamol Inhaler can be used to treat acute dyspnea attacks and can also be used as a preventative measure before physical activity or to stop exercise-induced asthma.
Pharmacology
The 2-adrenoceptor is a selective agonist of salbutamol. It has therapeutic effects on the 1-adrenoceptors of cardiac muscle but little to no effect on the 2-adrenoceptors of bronchial smooth muscle. Salbutamol causes short-acting (4-6 hours) bronchodilation with a rapid onset in reversible airway obstruction (within 5 minutes). By acting as an anti-inflammatory on mast cells, it also prevents the release of bronchoconstrictor mediators like histamine, neutrophil chemotactic factor (NCF), and prostaglandin D2.
Dosage & Administration
Salbutamol tablet or syrup-
Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily)
Adults: 2-4 mg tablet, 3-4 times daily. The maximum single dose is 8 mg tablet.
Salbutamol Respirator Solution: To be used with a suitable nebulizer device under the direction of a physician. The solution must not be injected or ingested.
Method-1 (Intermittent Administration):
Method-2 (Continuous administration): 1-2 ml solution is diluted to make up to 100 ml with normal saline solution. The diluted solution is administered by a suitable nebulizer device. When there is a risk of anoxia through hypoventilation, oxygen should be added to the inspired air.
Salbutamol nebulizer solution: To be used with a suitable nebulizer device under the direction of a physician. The solution must not be injected or ingested.
Salbutamol injection:
Adults:
Children and Adolescents (<18 years of age): The dosage of Salbutamol infusion solution in the pediatric age group has not been established. At present, there are insufficient data to recommend a dosage regimen for children.
Salbutamol Inhalation Capsule:
Excercise-induced Asthma:
Interaction
Salbutamol and non-selective beta-blocking drugs such as propranolol should generally not be prescribed together. Potentially serious hypokalaemia may result from β2-agonist therapy. Particular caution is advised in acute severe asthma as this effect may be potentiated by concomitant treatment with xanthine derivatives, steroids, diuretics, and hypoxia. It is recommended that serum potassium levels are monitored in such situations.
Contraindications
Salbutamol inhaler is contraindicated in patients with a history of hypersensitivity to salbutamol or any other components of Salbutamol inhaler.
Side Effects
Salbutamol is easily tolerated by most people. During inhalation, just a few adverse effects have been recorded. Tremors, anxiety, muscle cramps, headache, palpitation, a compensatory slight rise in heart rate, cardiac arrhythmias (including atrial fibrillation, supraventricular tachycardia, and extrasystoles), and tachycardia are all possible symptoms. Salbutamol inhalation can cause mouth and throat discomfort.
Pregnancy & Lactation
Pregnancy Classification C. In pregnant women, there are no sufficient and well-controlled studies using salbutamol inhalers or salbutamol sulfate. During pregnancy, this inhaler should only be used if the possible benefit outweighs the potential risk to the fetus. The components of the Salbutamol inhaler are not known to be excreted in human milk. When administering this inhaler to a nursing mother, exercise caution.
Precautions & Warnings
Storage Conditions
Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.
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